Veit Hornung

The IKK complex and TBK1/IKKε are recruited to STING through distinct mechanisms to activate NF-κB signaling.

Stimulator of interferon genes (STING) is a highly conserved signaling molecule that coordinates an antiviral innate immune response through activation of the nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways. In addition to an antiviral response, STING-mediated NF-κB signaling also...

SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.

Forward genetic screening links genotype to phenotype by introducing random genetic perturbations and identifying phenotype-altering mutations. Although genome-scale screens are routine for simple phenotypes in cultured cells, extending them to complex image-based phenotypes remains challenging. Here, we present spatia...

Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization

It is established that mitochondrial protein import couples translation-associated proteotoxic stress to mitochondrial injury and regulation of import flux as a determinant of mitochondrial integrity during proteostasis failure.

Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology