Author

Veronica E. Farag

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Open access Sep 2026

Dual-Targeted Inhibition of PAR2 Endosomal Signaling in Synoviocytes and Nociceptors Attenuates Osteoarthritis Pain

It is established that PAR2 signaling in neurons is critical for OA nociception and that nanoparticle delivery of PAR2 antagonists (PAMAM-Chol-AZ3451) represents an effective strategy for sustained inhibition of PAR2 activity, offering a novel approach for managing chronic OA pain.

Marcella de A. Ferreira, Paz Duran, Raquel Tonello et al. · Nanomaterials · 0 citations

#gene editing Open access Sep 2026

Intracranial delivery of neuron-preferential lipid nanoparticles for gene-editing activity in mouse brain

Lipid nanoparticles (LNPs) are promising non-viral vectors for central nervous system (CNS) gene therapy, but effective delivery is limited by the blood-brain barrier and cell-type specificity. Here, we combined intracranial delivery with high-throughput, cluster-based screening and machine learning to identify LNP for...

S. S. Cai, Cody Slater, Veronica E. Farag et al. · Cell Reports Physical Scienc... · 0 citations