Vinayak Agarwal

Shape Shifting Proteusin Peptides and Their Multimodal Binding Interactions Underlie RiPP Biosynthesis

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are produced through the selective recognition and enzymatic modification of precursor peptides. While canonical RiPP leader peptides are generally short and unstructured, the discovery of nitrile hydratase-like leader peptides (NHLPs) has rev...

Tertiary structure of a Nif11-like leader peptide mediates protein-protein interactions with a RiPP biosynthetic enzyme

New design of a chimeric enzyme based on vanadium-dependent bromoperoxidase and glucose oxidase to highlight the microbicidal properties of the reaction products: HOBr and HOCl.

Vanadium-dependent haloperoxidases are enzymes found in bacteria, fungi and red or brown macroalgae. They are used as a defense system for the latter by producing bromoform. The intermediate product, HOBr or HOCl, is also a microbicidal compound that can be exploited in many domains as medical tools or disinfectant spr...