Conformational insights into the unfolding pathway of RNA recognition motif (RRM) domain of TAF15 associated with amyotrophic lateral sclerosis.
An extensive molecular dynamics simulations study to investigate the conformational dynamics and unfolding pathway of the TAF15-RRM domain in 8 M urea revealed that unfolding proceeds through stable, denaturant/temperature-accelerated partially unfolded intermediate ensembles that, by analogy with aggregation-prone int...