Author

W. Brum

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Open access Sep 2026

Brain‐derived plasma p‐tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change

Plasma phosphorylated tau (p‐tau), particularly p‐tau217, is a highly specific biomarker of Alzheimer's disease (AD) pathology. However, plasma p‐tau217 can be elevated in rare non‐AD conditions. Brain‐derived (BD) p‐tau217 may reduce these off‐target effects, but its performance against neuropathology has not been eva...

Marisa N. Denkinger, W. Brum, A. Leuzy et al. · Alzheimer's & Dementia · 0 citations

Open access Aug 2026

Plasma Biomarkers for Neocortical Tau Burden.

This multicohort study demonstrated how including additional plasma proteins significantly enhanced the performance of p-tau217 in predicting advanced tau pathology among amyloid-positive individuals, suggesting a multiprotein approach may offer a viable and scalable alternative to tau PET staging in clinical or resear...

Guglielmo di Molfetta, W. Brum, I. Pola et al. · JAMA Neurology · 1 citation