Open access
Brain‐derived plasma p‐tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change
Marisa N. Denkinger
W. Brum
A. Leuzy
Alpana Singh
Tainá M. Marques
Valentina Ghisays
Hillary D. Protas
Yi Su
A. Atri
Thomas G. Beach
G. Serrano
K. Bhatt
C. Carlson
Katharine Hoffmann
E. Reiman
N. Ashton
Medicine
Abstract
Plasma phosphorylated tau (p‐tau), particularly p‐tau217, is a highly specific biomarker of Alzheimer's disease (AD) pathology. However, plasma p‐tau217 can be elevated in rare non‐AD conditions. Brain‐derived (BD) p‐tau217 may reduce these off‐target effects, but its performance against neuropathology has not been evaluated.