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Review Sep 2026

Annotation of Cell Types in Single-Cell Sequencing for Cardiovascular Disease: Concepts, Workflows, Challenges, and Best Practices.

This Review systematically integrates current conceptual frameworks, computational methodologies, and domain-specific best practices for cell-type annotation in cardiovascular single-cell research and offers practical recommendations and discuss future directions encompassing multimodal integration, spatial transcripto...

Lu Sun, Li Ma, Li-Zhi Chen et al. · 0 citations
Aug 2026

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.

The expression of the circRNA circKLHL20_009 was significantly upregulated in the myocardium of patients with heart failure and in human cardiomyocytes treated with angiotensin II and an artificial circRNA sponge, circSPmiR31, effectively mitigated cardiac hypertrophy and fibrosis by suppressing miR-31-5p binding to Dk...

Yi-hong Wen, Jia-xue Jiang, W. Dong et al. · 0 citations

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