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The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.

Yi-hong Wen Jia-xue Jiang W. Dong Jing Guo Qing-Yue Hu Xiao-yao Liu Zhen-Zhen Yang Lu-fang Huang Jie-ning Zhu Meng-Zhen Zhang Xi-Pei Wang Yupeng Liu Ning Ma Xi-Long Zheng W. Cai Jin-dong Xu Xian-hong Fang Zhi-xin Shan
Aug 2026 · Acta Pharmacologica Sinica · 0 citations · 41 references
Medicine

TL;DR

The expression of the circRNA circKLHL20_009 was significantly upregulated in the myocardium of patients with heart failure and in human cardiomyocytes treated with angiotensin II and an artificial circRNA sponge, circSPmiR31, effectively mitigated cardiac hypertrophy and fibrosis by suppressing miR-31-5p binding to Dkk1 mRNA.

DOI PubMed Semantic Scholar
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