Author

W. Freeman

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Open access Oct 2026

Female microglia show heightened responses to aging and amyloid pathology in mice and humans

INTRODUCTION Alzheimer’s disease (AD) displays pronounced sex differences, with women exhibiting greater prevalence and pathological burden than men. However, the molecular mechanisms underlying these differences remain elusive. Translation of preclinical findings to human AD remains challenging, potentially due to lim...

Jillian E. J. Cox, Ewa Poljańska, Sarah Ray et al. · bioRxiv · 0 citations

Open access Oct 2026

Functional and molecular profiles of the neuroretina and retinal pigmented epithelium-choroid in response to aging and Nrf2 deletion

Alation of Nrf2 exacerbates age-related declines suggesting that decrease in Nrf2 with aging has functional consequences for inflammation/resiliency.

Becca L. Wells, A. Filiberti, David R. Stanford et al. · bioRxiv · 0 citations