Purpose The neural retina and retinal pigment epithelium/choroid (RPE/Cho) are metabolically coupled. Metabolic dysfunction of the RPE/Cho contributes to photoreceptor death in age-related macular degeneration (AMD). This study aimed to determine how aging, a major risk factor for AMD, alters the proteome and metabolic...
Findings suggest that MTRNR2L genes participate in coordinated stress-adaptive programs and may mirror humanin’s cytoprotective and immunomodulating actions in RPE protection and AMD progression.
Adam Moosa, J. Wang, Margaret M. DeAngelis et al.· Frontiers in Immunology· 0 citations
Purpose The purpose of this study was to test for abnormal optical coherence tomography (OCT) metabolic biomarker patterns in the A53T Parkinson's disease model, which accumulates α-synuclein in photoreceptor inner segments before overt motor symptoms. Methods Four-to-6-month-old transgenic A53T homozygous mice and B6C...
Ehimenmen S. Ataman, C. T. O. Nguyen, D. I. Finkelstein et al.· Investigative Ophthalmology...· 0 citations
Purpose The purpose of this study was to noninvasively test the hypothesis that dysregulated photoreceptor metabolism occurs with early retinal degeneration in dark-reared Pde6brd10 mice. Methods Postnatal day 23 (P23) phosphodiesterase (PDE) mutant (Pde6brd10) mice, P23 wild-type (WT) mice were continuously dark-reare...
Bruce A. Berkowitz, Robert H. Podolsky, Rida Waseem et al.· Investigative Ophthalmology...· 0 citations
Retinitis pigmentosa (RP) is accompanied by retinal oxidative stress and neuroinflammation, but whether local retinal stress is associated with detectable circulating molecular changes remains unclear. Using RhoP23H/+ mice at postnatal days 40, 90, and 240, we combined electroretinography, hematoxylin and eosin (H&E)-b...
Yuzhuo Fan, Jia-Rui Li, Wei Du et al.· Experimental and molecular p...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.