Highlights This review highlights the growing potential of microbiome research to broaden understanding of Alzheimer’s disease. While the gut and oral microbiomes currently provide the strongest evidence, the ocular microbiome represents an exciting emerging area, supported by the close biological relationship between...
S. K. Mishra, Jerome Ozkan, Fei-Fei Su et al.· Cells· 0 citations
Although amyotrophic lateral sclerosis (ALS) has traditionally been viewed as a motor neuron-centered disease manifesting by muscle wasting and weakness, growing evidence indicates that disease progression is strongly influenced by interactions between motor neurons and surrounding glial cells. Astrocytes are major r...
W. S. Kim, H. Timmins, L. Van Den Bosch et al.· Cellular and molecular neuro...· 0 citations
Evidence is assessed that astrocytic lipid metabolism is not solely protective or pathological but has instructive physiological roles and that astrocytic lipid dysregulation is an early driver of neurodegeneration, and targeting of astrocytic lipid homeostasis represents a promising strategy for preventing or minimizi...
W. S. Kim, G. Halliday· Nature Reviews Neurology· 1 citation
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