Astrocytic lipid dysregulation as an early driver of neurodegeneration

Astrocyte Lipid Metabolism: From Physiological Homeostasis to Reactive Phenotype Plasticity in Neurodegeneration.

A systematic review of recent advances in astrocyte lipid metabolism is provided, summarizing the fundamental roles of astrocytes in the CNS and focusing on the biosynthesis, degradation, and trafficking mechanisms of fatty acids, cholesterol, and the tightly linked organelles known as lipid droplets.

Disrupted astrocyte-neuron metabolic coupling in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by progressive loss of motor neurons. In addition to neurodegeneration, ALS is increasingly recognised as a disorder associated with widespread metabolic dysfunction, including hypermetabolism, weight loss, and dyslipidaemia, all of...

From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases

A microglial immunometabolic trajectory framework is proposed in which metabolic states are viewed as branching and potentially reversible determinants of cellular function rather than fixed stages of a universal disease pathway.

Brain lipid dysregulation as a driver of energy metabolism failure in Alzheimer's disease.

This chapter addresses the gap and consolidates existing information connecting lipid modifications to metabolic dysfunction in AD, emphasizing molecular pathways and prospective treatment strategies aimed at lipid metabolism to re-establish bioenergetic equilibrium.

Astrocyte Structure–Function Relationship in Senescence and Neurodegeneration

Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson’s disease

This review systematically summarizes current research on astrocyte involvement in PD pathology and their neuronal interaction mechanisms, further exploring their interconnections to elucidate disease pathogenesis.