Increasing clinical use of fluoroquinolone antibiotics has led to a rapid surge in fluoroquinolone-resistant Salmonella strains, markedly constraining the therapeutic armamentarium and increasing treatment failure risks. Epidemiological surveillance reveals high prevalence rates of resistant isolates across Asia, Afric...
A synthesis of the molecular mechanisms underlying aminoglycoside resistance in Enterobacteriaceae is provided, including the roles of aminoglycoside-modifying enzymes, high-level resistance mediated by 16S rRNA methylation, alterations in bacterial membrane permeability, and heteroresistance.
Yi-Ting Lin, Ling Peng, Shuo-Jie Lv et al.· Frontiers in Cellular and In...· 0 citations
This work provides a theoretical framework for prevention, diagnosis, and targeted intervention of MAP-associated disorders and critically assess diagnostic limitations—particularly the inability of polymerase chain reaction (PCR) to distinguish viable from non-viable organisms.
Ruo-Xi Tao, Wan-Ying Zheng, Ling Peng et al.· Frontiers in Immunology· 0 citations
An orally administered cobalt single‐atom nanozyme featuring pH‐responsive, bifunctional catalytic activity to enable simultaneous intestinal radioprotection and tumor radiosensitization is developed, offering a promising paradigm to substantially widen the therapeutic window of radiotherapy.
Shengqi Yin, Jun-Jie Li, Yi-Shu Zou et al.· Advancement of science· 1 citation
Specific mechanisms by which the gut microbiota affects depression through the aforementioned pathways are reviewed, including regulating the balance of neurotransmitters, mediating neuroinflammatory responses, and adjusting the levels of metabolites such as short-chain fatty acids.
