Sep 2026· Frontiers in Cellular and Infection Microbiology· Vol 16· 0 citations· 97 references
Medicine
TL;DR
A synthesis of the molecular mechanisms underlying aminoglycoside resistance in Enterobacteriaceae is provided, including the roles of aminoglycoside-modifying enzymes, high-level resistance mediated by 16S rRNA methylation, alterations in bacterial membrane permeability, and heteroresistance.
Abstract
Enterobacteriaceae, as common clinical pathogens, pose a significant threat to global public health because of the infections they cause. Aminoglycoside antibiotics are critical for treating these infections; however, increasing antimicrobial resistance severely limits their clinical efficacy. This review provides a synthesis of the molecular mechanisms underlying aminoglycoside resistance in Enterobacteriaceae, including the roles of aminoglycoside-modifying enzymes, high-level resistance mediated by 16S rRNA methylation, alterations in bacterial membrane permeability, and heteroresistance. These resistance mechanisms are typically mediated by mobile genetic elements such as plasmids and integrons, facilitating rapid dissemination among bacterial strains. This review aims to provide a theoretical foundation for optimizing clinical antimicrobial strategies, developing novel therapeutic agents, and establishing effective surveillance frameworks.
AMR develops as a result of microbial evolution under selective pressure imposed by
antimicrobial use. Although antimicrobial resistance occurs in bacteria, fungi, viruses, and parasites,
this review specifically focuses on bacterial antimicrobial resistance resulting from antibiotic
exposure. The mechanisms, cause...
D. M. Syukri, T. Oladosu, S. Shafi et al.· Anti-Infective Agents· 0 citations
This article provides an in-depth review of the molecular mechanisms responsible for bacterial multidrug resistance (MDR), including efflux pump overexpression, enzymatic inactivation, target modification, and biofilm-associated tolerance. A structured literature search of major academic databases (PubMed, Google Schol...
Patrycja Przebieradło, Patrycja Rędziniak, Monika Rajs et al.· International Journal of Inn...· 0 citations
Critical insights into the development of multidrug resistance in nosocomial pathogens are provided and could enlighten novel drug designs and strategies to combat infections in both clinical and environmental settings.
The emergence and evolution of antimicrobial agents have revolutionized modern medicine, enabling the
effective treatment of bacterial and fungal infections. This article reviews the main mechanisms of action of
antibacterial and antifungal agents, including inhibition of cell wall synthesis, protein synthesis, plasm...
Maria E. P. de O. Silva, Rebeca Azevedo de L. Madeira, D. L. de Souza et al.· SVOA Microbiology· 0 citations
Antimicrobial resistance (AMR) is a global public health challenge with remarkable impacts on human, animal, and environmental health within the One Health framework. Among the pathogens most frequently associated with healthcare-associated infections are bacteria belonging to the ESKAPEE group, which comprises Enteroc...
Damaris Krul, Alana Araújo Braga, D. Conte et al.· Antibiotics· 0 citations
Antimicrobial resistance (AMR) has arisen as a paramount worldwide public health challenge of the
twenty-first century, with Klebsiella pneumoniae identified as a key priority pathogen by the World
Health Organization. This
opportunistic Gram-negative bacterium causes several healthcare-associated and community-acquire...
Kajal Verma, H. Sidhu· International Journal of Dru...· 0 citations
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