Background Myocardial ischemia/reperfusion (MI/R) injury involves oxidative stress, lysosomal dysfunction, and altered autophagy. TRPV4 may link Ca2+ dysregulation to these processes, but its role in lysosomal membrane permeabilization (LMP) and autophagic impairment remains unclear. Methods Three disease-matched mouse...
Jie Yang, Jin-Cheng Li, Guan-Yao Li et al.· Frontiers in Cell and Develo...· 0 citations
INTRODUCTION
Sepsis imposes an overwhelming global critical care burden, contributing to an estimated 49 million annual deaths worldwide. Although multiple sepsis-related metabolic profiles have been characterized in prior research, no metabolomic biomarkers have yet entered routine clinical prognostic practice. This s...
Jing Xu, Zhou Huang, He Li et al.· Journal of Surgical Research· 0 citations
The administration of SrEG + NIR offered the perfect therapeutic effects in CP‐AKI rats by inhibiting the PI3K/AKT pathway, thus accelerating kidney function repair and showed substantial clinical promise as a potential therapeutic strategy in ROS‐related diseases.
Tet-NCs provide superior therapeutic effects in RA compared to conventional Tet tablets, and their mechanism of action may involve the regulation of inflammation through inhibition of the JAK1/STAT3 signaling pathway.
Guang-Zhao Wang, Jian Mo, Wenxiu Huang et al.· The Journal of pharmacy and...· 0 citations
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