Aug 2026· The Journal of pharmacy and pharmacology· Vol 78 8· 0 citations
Medicine
TL;DR
Tet-NCs provide superior therapeutic effects in RA compared to conventional Tet tablets, and their mechanism of action may involve the regulation of inflammation through inhibition of the JAK1/STAT3 signaling pathway.
Rheumatoid arthritis (RA) is a chronic autoimmune disease with a global prevalence of 0.5% to 2%, causing serious impairment and early mortality. Presently approved therapeutics comprising non‐steroidal anti‐inflammatory drugs (NSAIDs), disease‐modifying anti‐rheumatic drugs (DMARDs), corticosteroids, etc. only lower p...
K. Kolekar, Bushra Bashir, P. Kumbhar et al.· Advanced Healthcare Material...· 0 citations
This review systematically summarizes the pharmacodynamic basis and molecular mechanisms underlying the anti-RA effects of natural polysaccharides reported since 2000, with particular emphasis on recent advances in novel drug delivery technologies and a critical evaluation of clinical application studies.
Lu-Xin Li, Jun-Nan Li, Guang-Zhi Li et al.· Phytotherapy Research· 0 citations
Background Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by severe synovial inflammation, joint deformities, and progressive tissue destruction. Celastrol (Cel), a natural triterpenoid with anti-inflammatory and antioxidant activity, is a promising therapeutic candidate for RA; however, its a...
Ji-Quan Shen, Chang-Jian Zhou, Xing-Gao Wang et al.· Frontiers in Immunology· 1 citation· ⚡1
It is demonstrated that Peedanil Gold has pharmacological effects in an animal model of rheumatoid arthritis, as evident by reduced arthritis score, alleviation of paw and ankle swelling, improvement in pathological lesions as observed radiologically and histopathologically.
A. Balkrishna, Sonam Sharma, Aakanksha Tiwari et al.· Frontiers in Pharmacology· 0 citations
A nanoemulsion based gel loaded with the β-CD-MTX inclusion complex provides a hopeful approach to enhance topical MTX delivery, improves therapeutic efficacy, and reduces systemic side effects, thereby addressing important limitations of traditional RA therapy.
Aman Kumar, R. Pal, Manish Kumar et al.· BioNanoScience· 1 citation· ⚡1
Collectively, cepharanthine mitigates joint inflammation and structural damage in RA by inhibiting the AGE/RAGE/rat sarcoma viral oncogene homolog (Ras)/nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling cascade.
Bao Hou, Ming-Tao Yang, Hao-Ting Liu et al.· European Journal of Pharmaco...· 0 citations
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