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Author

Wei Zhang

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Review Jul 2026

Glypican-3-targeted therapy in hepatocellular carcinoma: biological insights and therapeutic strategies

Biological and translational evidence is synthesized to examine factors that may constrain the clinical efficacy of GPC3-targeted therapies, including antigen-related features, tumor microenvironment–associated barriers, and platform-specific challenges.

Na Li, Shu-Rong Li, P. Cao et al. · 1 citation
Jul 2026

Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.

It is demonstrated that Lamtor5 ablating macrophages displayed senescent signatures, metabolic defects, aging-related transcriptomic and epigenetic features, nicely concurring with macrophages from naturally aging mice, opening a new avenue for developing macrophage-based therapeutics to improve healthy aging.

Nianyin Lv, Yunzhe Tang, Wei Zhang et al. · 0 citations

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