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Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.

Nianyin Lv Yunzhe Tang Wei Zhang Qimeng Zhang Hairui Zhang Hainv Gao Shu-Mao Cui Sergei Krasny Liyun Shi
Jul 2026 · Cell Death and Differentiation · 0 citations · 27 references
Medicine

TL;DR

It is demonstrated that Lamtor5 ablating macrophages displayed senescent signatures, metabolic defects, aging-related transcriptomic and epigenetic features, nicely concurring with macrophages from naturally aging mice, opening a new avenue for developing macrophage-based therapeutics to improve healthy aging.

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