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Nonlinear Functional Connectivity and ICA Reveal Default Mode Network Hyperconnectivity in Parkinson’s Disease: A Resting-State fMRI Study
It is demonstrated that nonlinear FC enhances sensitivity to PD-related network alterations, while spatial features highlight clinically relevant biomarkers and contributes to the methodological development of resting-state fMRI and its translational application to PD.
PGP-Clinical-TimeKAN: Prior-Guided Joint Probabilistic Forecasting of Clinical Trajectories
Clinical deterioration unfolds through coupled, partially observed trajectories, not a single diagnostic label. We introduce PGP-Clinical-TimeKAN, a trajectory-first framework for joint probabilistic forecasting of multivariate physiology. It combines missingness-aware temporal encoders, a soft organ-system prior, pati...