Skip to content
Log in
Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Nonlinear Functional Connectivity and ICA Reveal Default Mode Network Hyperconnectivity in Parkinson’s Disease: A Resting-State fMRI Study

Charles Okanda Nyatega Qiang Li Weizhi Nie Farhan Ahmad Mohammed Jajere Adamu
Aug 2026 · Brain Topography · Vol 39 · 0 citations · 32 references
Medicine

TL;DR

It is demonstrated that nonlinear FC enhances sensitivity to PD-related network alterations, while spatial features highlight clinically relevant biomarkers and contributes to the methodological development of resting-state fMRI and its translational application to PD.

DOI PubMed Semantic Scholar
View source

Similar papers

Aug 2026

Structural Connectivity Alterations Within Frontal Subregions in Parkinson's Disease: Implications for Motor Dysfunction.

Intraregional topological reorganization within the frontal lobe, most prominently in RMF.L, was associated with motor impairment in PD and may reflect maladaptive network remodeling, and high-resolution network analysis may provide a sensitive framework for characterizing intraregional structural reorganization.

Yue Yuan, Xue Chen, Yan-De Ren et al. · 0 citations
Open access Sep 2026

Altered Inter‐Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting‐State fMRI Analysis

ABSTRACT Background Speech impairment is common in Parkinson's disease (PD) and lacks effective clinical interventions due to poorly understood underlying mechanisms. Therefore, this study aimed to explore the relationship between altered brain functional networks and speech impairments in PD, identifying neural correl...

Shan Deng, Yong-Qing Xiao, Zi-Mei Dong et al. · 0 citations
Open access Sep 2026

Distance-dependent Functional Connectivity Strength Analysis Using Resting-State fMRI: Application to Vascular Cognitive Impairment, No Dementia.

We present a resting-state fMRI-based protocol for quantifying anatomical distance-dependent functional connectivity strength (FCS) and demonstrate its application in vascular cognitive impairment, no dementia (VCIND). Resting-state fMRI data from VCIND patients and demographically matched normal controls were analyzed...

Qiong-Ge Li, Y. Xing, Shan Yi et al. · 0 citations
Sep 2026

Enhanced local neural compensation accompanied by global functional decline in Binswanger's Disease with mild cognitive impairment: loss of whole-brain integration and dynamic flexibility in resting-state networks.

The neurobiological basis of cognitive impairment in Binswanger disease remains unclear. We compared 21 Binswanger disease patients with mild cognitive impairment (BD-MCI) and 21 without cognitive impairment (BD-C) using resting-state fMRI. No healthy control group was included. All participants completed cognitive ass...

Hai-Yi Zhang, Juan Lu, Jia-Jun Yue et al. · 0 citations
Sep 2026

Cerebellar Alteration in Resting-State Functional Connectivity Among Kratom (Mitragyna speciosa) Users: Insights from Functional MRI.

Chronic kratom consumption may alter brain activity, especially in areas linked to the DMN, cognition, and reward processing, and enhanced FC between salience and cerebellar networks may reflect compensatory mechanisms or adaptations to kratom's effects.

Suzana Mat Isa, A. A. Abd Hamid, Muhamad Zabidi Ahmad et al. · 0 citations
Open access Aug 2026

Target-level convergence of directional prefrontal connectivity across Alzheimer’s disease stages: an fNIRS study

It is suggested that MCI and AD are associated with distinct patterns of directional information flow within prefrontal networks, characterized by reduced convergence toward FPC-R and increased directional influence toward DLPFC-L.

N. Mateen, Rana Muhammad Kaleem Ullah, Jisoo Baik et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.