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Wen-Ping Wei

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#protein folding Sep 2026

Engineering a Transcription Activation Toolkit by Rewiring Prokaryotic Transcription Factors and Synthetic Yeast Promoters in Yarrowia lipolytica

Yarrowia lipolytica is a promising industrial host, yet its metabolic engineering potential remains limited by insufficient genetic tools. Here, we engineered a synthetic Transcription Activation Toolkit (TAT) based on LacI–VPRH, a chimeric protein fusing the prokaryotic DNA-binding domain LacI with the eukaryotic ac...

Yunhe Li, Wen-Ping Wei, Ping Zhang et al. · 0 citations
Open access Aug 2026

Discovery of a taxusin-mediated route to baccatin III enables its complete biosynthesis in engineered microbes

Taxol (paclitaxel) is a frontline anticancer drug widely applied for the treatment of breast, ovarian and lung cancers. Currently, its supply mainly relies on the semi-synthesis using baccatin III from Taxus plants. Heterologous biosynthesis of baccatin III in microorganisms offers a promising solution to alleviate glo...

Chengshuai Yang, Zhenhua Li, Linjie Yu et al. · 0 citations

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