A Repurposed S-Adenosyl-l-Methionine Synthetase Mediates Cytidyl-Cyclitol Natural Product Assembly.
Nucleoside natural products exhibit diverse chemical architectures and potent biological activities, yet the biosynthetic strategies that generate their structural diversity remain incompletely understood. Here, we elucidate the early stage biosynthetic pathway of the cytidyl-cyclitol natural product K-563 and its deri...