Author

Wiktoria Mallek

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#protein folding Review Open access Oct 2026

DAPEG, a Modular Peptidomimetic Concept for Intracellular Delivery: Architecture, Trajectory, and Outlook in the Context of Peptidomimetic Transfection Reagents

Cell-penetrating peptides (CPPs) remain a leading nonviral strategy for the intracellular delivery of polynucleotides and folded proteins, but native α-peptide CPPs are constrained by proteolysis, dose-dependent cytotoxicity, and endosomal entrapment. Peptidomimetic redesign addresses these limitations by replacing t...

Wiktoria Mallek, Gabriela Mirecka, M. Wysocka · ACS Omega · 0 citations

Review Aug 2026

Targeting peptidylarginine deiminases 2 and 4 in diabetic kidney disease: mechanistic rationale and preclinical evidence.

PAD inhibition should be framed as a mechanistically distinct, still-preclinical adjunct to the KDIGO 2024 standard of care, with its renal potential depending on isoform-resolved human data and pharmacokinetic characterization in chronic kidney disease.

Wiktoria Mallek, Aleksandra Wróblewska-Schmude, Adam Lesner et al. · Biochemical Pharmacology · 0 citations