Author

Xi-Yun Yan

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#protein folding Oct 2026

Nanoconfined Protein Scaffold as a Generalizable Platform Empowers Synergistic Enzyme–Nanozyme Catalysis for Cascade Biotransformation

Enzymatic and chemoenzymatic cascades hold immense potential for industrial applications but are hindered by inherent instability, low atom economy, inefficient intermediate transfer, and complex enzyme immobilization processes. Here, we repurpose encapsulin, which naturally loads cargo, as a programmable nanoreactor...

Zi-Xia Zhang, Ruo-Fei Zhang, Xue-Jiao J. Gao et al. · ACS Nano · 0 citations

Open access Aug 2026

Phage-Derived Protein-Guided Nanozymes for the Treatment of MRSA-Infected Acute Otitis Media.

A single-atom nanozyme is reported by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Staphylococcus aureus phage via a bioorthogonal reaction to achieve targeted catalytic elimination of methicillin-resistant Staphylococcus aureus (MRSA).

Bin Hong, Jie Wang, Bing Hu et al. · Small · 0 citations