Ultra-processed foods (UPFs) have become dominant in modern diets, yet their relationship with atherosclerosis—the primary pathological basis of cardiovascular disease—remains inadequately characterized. We investigated the association between UPF consumption and incident atherosclerosis risk and explored underlyin...
Yi-Xin Zhao, Yu-Guang Li, Xiang-Liang Liu et al.· Frontiers in Nutrition· 0 citations
Circulating tumor DNA (ctDNA) is emerging as a minimally invasive biomarker for risk stratification and treatment-response assessment in lung cancer immunotherapy, but its routine use for treatment selection has not been established. This review critically evaluates evidence across neoadjuvant, adjuvant, consolidation...
Yan Li, Guan-Yu Lu, Wei Song et al.· Frontiers in Immunology· 0 citations
Low-dose CT (LDCT) lung cancer screening significantly reduces mortality but has dramatically increased the detection of pulmonary nodules. Most of these nodules are benign, leading to a high false-positive rate that triggers unnecessary invasive procedures and patient anxiety, underscoring the need for more precise no...
Yan Li, Guanyu Lu, Xiangliang Liu et al.· Critical reviews in oncology...· 0 citations
This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...
Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al.· Biochimica et biophysica act...· 0 citations
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