#protein folding
Oct 2026
Deep-Learning-Driven Discovery and Engineering of Imine Reductase for the Efficient Synthesis of Chiral Opine Derivatives
The narrow amine donor scope of imine reductases (IREDs) limits their application in the synthesis of opine compounds. Herein, we report a machine learning (ML)-guided protein engineering strategy to address this limitation. An IRED from an unclassified Ensifer, IRED5, was identified through deep-learning-based scree...
Jia-Neng Xu, Min-Min Zhao, Cheng Xu et al.
· ACS Catalysis · 0 citations