Mapping the molecular landscapes within subcellular compartments is critical for understanding cellular function. Photocatalytic proximity labeling has emerged as an increasingly diversified chemical strategy for interrogating biomolecular microenvironments in living systems. However, a modular small-molecule platform...
Mei-Han Hou, Lin-Ao Ren, Xin Xi et al.· JACS Au· 0 citations
Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest protein factor regulating developmental...
The development of tumor-targeting agents is of great significance for cancer therapy. Despite the promising potential of Boron Neutron Capture Therapy (BNCT), efficient and selective accumulation of boron-10 agents in cancer cells remains challenging. Conjugation of carborane with tumor-targeting ligands provides an a...