Author

Xiao-Chuan Wang

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Open access Sep 2026

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI), but therapeutics that modulate key inflammatory amplifiers remain limited. Here, we identify infiltrating macrophages as the predominant TREM1‐expressing population in TBI human and mouse brain and show that TREM1 deletio...

Yi-Min Huang, Yuan Liu, Huan Peng et al. · Advancement of science · 0 citations

Aug 2026

Astrocytic LCN2 mediates pathological crosstalk with neurons to promote neuronal loss in sepsis-associated encephalopathy.

This study demonstrates that increased secretion of LCN2 from hippocampal astrocytes in SAE mice binds to the neuronal receptor 24p3R, thereby inducing neuronal damage and suggests an etiopathogenic mechanism of SAE, initiated by the increased astrocytic secretion of LCN2.

Cui-Ping Guo, Yi Liu, Wensheng Li et al. · Cell Death and Differentiati... · 0 citations