Astrocytic LCN2 mediates pathological crosstalk with neurons to promote neuronal loss in sepsis-associated encephalopathy.

α7nAChR alleviates cognitive impairment by promoting autophagy in astrocytes via CaMKK2/AMPK/mTOR pathway in sepsis-associated encephalopathy

Background Sepsis-associated encephalopathy (SAE) is a syndrome of cerebral dysfunction secondary to sepsis. Although the α7 nicotinic acetylcholine receptor (α7nAChR) plays a pivotal role in the SAE, the specific mechanisms by which it mediates neuroinflammatory responses and contributes to pathological injury in SAE...

CD300f negatively regulates microglial pyroptosis via the JAK2/STAT3 axis in sepsis-associated encephalopathy.

Sepsis-associated encephalopathy (SAE) is a multifactorial medical condition characterized by pronounced neuroinflammation and linked to increased mortality risk and long-term cognitive impairment. Microglial pyroptosis has emerged as a crucial pathogenic mechanism in SAE. CD300f, an immune receptor expressed in microg...

Thymosin β4 Mitigates Acute Cerebral Infarction Via Inhibition of the TLR4/NF-κB Pathway and Suppression of Neuronal Pyroptosis.

Tβ4 exerts neuroprotective effects against ACI by suppressing the TLR4/NF-κB signaling pathway and mitigating neuronal pyroptosis and mitigating neuronal pyroptosis, demonstrating potential clinical application value.

NLRP3 Regulation in Neonatal Hypoxic–Ischemic Encephalopathy—Focus on Microglial Activation

Neonatal hypoxic–ischemic encephalopathy (HIE) is a major cause of neonatal mortality and long-term neurological disability, affecting 1–3 per 1000 live births in developed countries and occurring at substantially higher rates in developing countries. Neuroinflammation is a key contributor to disease progression, with...

FPR1 drives sepsis-associated cognitive impairment through region-specific transcriptional and splicing dysregulation in the brain

Targeting microglial glutaminase 1 protects against ferroptosis-driven cognitive impairment in perioperative neurocognitive disorders.

Perioperative neurocognitive disorders (PND) are common neurological complications in elderly surgical patients, for which effective mechanism-based therapies remain lacking. This study identifies ferroptosis, an iron-dependent lipid peroxidation-driven cell death, as a key pathological process in PND, and pharmacologi...