Author

Xiao-Hong Sun

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#gene editing Review Open access Sep 2026

Pathogenesis and precision management of osteogenesis imperfecta: from genetic mechanisms to novel therapies.

BACKGROUND Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous skeletal dysplasia characterized by systemic bone fragility. Beyond skeletal manifestations, OI is a multisystem condition involving dentinogenesis imperfecta, hearing loss, joint hyperlaxity, and cardiopulmonary complications. The di...

Xue-Qian Wang, Cai Zhang, Xin Li et al. · World Journal of Pediatrics · 0 citations

Open access Sep 2026

PAQR3 Promotes Diabetic Tubulointerstitial Fibrosis by suppressing STUB1-mediated NOX4 ubiquitination.

Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, and tubulointerstitial fibrosis (TIF) represents its final pathological hallmark. Progestin and adipoQ receptor 3 (PAQR3) has been implicated in metabolism and inflammation, but its role in DKD remains largely unexplored. Here, we report that P...

Xiao-Hong Sun, Shi-Qiang Tan, Jia-Bi Wu et al. · Free Radical Biology & Medic... · 0 citations