Author

Xiao-Lei Zuo

2 papers indexed here

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Aug 2026

DNA Nanoruler-Assisted Linearization for Long-Chain Nucleic Acids Analysis.

Long-chain nucleic acids (LCNAs) are increasingly important as diagnostic biomarkers, yet their quantitative detection is often hindered by compact conformations that limit probe accessibility. Here, we report a DNA nanoruler-assisted linearization strategy that mechanically regulates LCNA conformation by employing a r...

Xi Yu, Shi-Lan Fu, Gang Liu et al. · Angewandte Chemie · 0 citations

#protein folding Sep 2026

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance.

This work establishes spatial conformation as a programmable parameter for regulating nanoparticle biodistribution and clearance, thereby shifting the design paradigm from compositional adjustment to architectural control and opening avenues for targeted delivery, imaging, and immunotherapy.

Qian Chen, Fei Ding, Shuang-Ye Zhang et al. · ACS Applied Materials and In... · 0 citations