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Xiaoqin Zou

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#protein folding Open access Aug 2026

Regulation of the human voltage-gated proton channel by membrane sterols

This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.

Shuo Han, R. Duan, Sarah Applewhite et al. · 0 citations
Review Jul 2026

The Advantages of AI for Computational Protein Studies and Looking Ahead at the Next Challenges: Single Structures Are Not Enough.

Addressing and predicting ligand-binding sites in protein structures, as well as the prediction of reliable structures of proteins interacting with other proteins, will be pivotal for fully details of structural mechanisms and dynamics.

Pradeep Bk, Shi-Jie Chen, R. Dima et al. · 0 citations