Author

Xiazhou Fu

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#gene editing Open access Sep 2026

A transdermal CRISPR/Cas9 strategy using biodegradable microneedles to target YB-1 in melanoma

Melanoma's aggressiveness and therapeutic resistance highlight the need for innovative strategies. This study developed a CRISPR/Cas9 ribonucleoprotein (RNP) system targeting the oncogenic YB-1 gene, combined with doxorubicin (DOX), delivered by chondroitin sulfate (CS)-based microneedles (MN) incorporating designed na...

Xiazhou Fu, Zhao-Yi Chen, Zi-Ru Zhang et al. · Materials Today Bio · 0 citations

Open access Aug 2026

MTCH2 acts as a novel inhibitory receptor to suppress germ cell mitophagy by tethering BECN1, thereby maintaining mitochondrial homeostasis and male fertility

These findings establish MTCH2 as an essential negative regulator of mitophagy that partners with BECN1 to maintain mitochondrial homeostasis, thereby ensuring normal spermatogenesis and male fertility.

Mengxing Cai, Rui-Fang Ren, Hui-Ling Shu et al. · Cell Death & Disease · 0 citations