Author

Xin Bai

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Review Open access Sep 2026

The mechanism of breast cancer stem cells and tumor microenvironment promoting radioresistance in breast cancer and its intervention strategies

This review provides a framework for rational trial design and precision RT in BC, and critically appraises translational barriers, including the paucity of validated biomarkers, the plasticity of BCSCs, and the toxicity profiles of multimodal regimens.

Ying Zhao, Xiao-Han Liu, Xin Bai et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

A TMED3-governed disulfidptosis-related diagnostic signature reveals tumor microenvironment remodeling in intrahepatic cholangiocarcinoma

This study provides a comprehensive single−cell atlas of ICC, identifies TMED3 as a key regulator of a disulfidptosis−related diagnostic signature, and demonstrates its functional role in promoting ICC malignancy.

Wan-Jia Qiao, Yixiang He, Jing Li et al. · Frontiers in Immunology · 0 citations

#protein folding Sep 2026

Ionizing radiation induces bidirectional transcriptomic reprogramming and dynamic NOS2/TREM2 regulation in triple-negative breast cancer cells.

Ionizing radiation was associated with broad bidirectional transcriptional remodeling in 4T1 cells, involving immune-, inflammatory-, and interferon-related signatures together with reduced representation of cell-cycle- and DNA-repair-related gene sets.

Jing Li, Xin Bai, Wan-Jia Qiao et al. · International Journal of Rad... · 0 citations

Review Open access Aug 2026

Optimizing immunotherapy–radiotherapy synergy in triple-negative breast cancer: mechanisms, clinical evidence, and therapeutic windows

The immunological characteristics of TNBC, the current status of ICI-based therapy, and the underlying mechanisms of resistance are reviewed, which summarizes the biological rationale for combining RT with ICIs in the treatment of TNBC and explores the impact of different RT dose-fractionation regimens, treatment seque...

Lu Wang, Xin Bai, Fan Wang et al. · Frontiers in Immunology · 0 citations