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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Xinhua Liu

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Oct 2026

Discovery of Novel Pyridazine-Containing Nicotinamide Derivatives as Potent FTO Inhibitors for Acute Myeloid Leukemia

FTO has been recognized as a promising therapeutic target for acute myeloid leukemia (AML). However, the development of FTO inhibitors with anti-leukemia effects was still limited. Here, based on reasonable design and SAR, a total of 67 compounds were synthesized, among which compound E6 exhibited the strongest activ...

Yu-Meng Wang, Ya-Ting Lu, Hao-Dong Liu et al. · 0 citations
#protein folding Sep 2026

Discovery of H-10 as a potent and safe GABAA receptor positive allosteric modulator: A novel benzothiazine-triazole lead compound with broad-spectrum anticonvulsant activity.

H-10 elicited dose-dependent seizure suppression and alleviated multi-organ pathological damage in both acute and chronic epileptic mouse models and is an orally bioavailable, efficacious GABAAR-targeted PAM with broad-spectrum antiseizure activity, deserving further optimization for anticonvulsant drug discovery.

Di Hu, Ying Wang, Jin-Ling Yu et al. · 0 citations
Aug 2026

Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.

LW-1 represents a promising CDK8 inhibitor with improved drug-like properties and potent anti-psoriatic efficacy, providing a potential therapeutic candidate for the treatment of psoriasis and other inflammatory diseases.

Cen-Cen Lei, Dawei Jin, A-Jun Liu et al. · 0 citations
Jul 2026

Discovery of novel hydroxycamptothecin derivatives as potent Topo I inhibitors for antitumor guided by molecular dynamics.

Camptothecin (CPT) and its derivatives are clinically validated topoisomerase I (Topo I) inhibitors with broad-spectrum antitumor activity and modification at the 10-position of the CPT scaffold represents a promising strategy to enhance binding affinity.

Yixuan Zhang, Hong Wang, Feilong Zhou et al. · 0 citations

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