Author

Xin Lu

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Open access Sep 2026

PYGO2 Ablation Promotes Lymphoid Organization and STING-Dependent Antitumor Immunity in Prostate Cancer.

Prostate cancer is an immunologically cold tumor with a limited response to immune checkpoint blockade. Although tertiary lymphoid structures (TLSs) are associated with favorable immunotherapeutic outcomes in various malignancies, the tumor-intrinsic mechanisms governing their formation in prostate cancer remain poorly...

Yi-Ni Zhu, Yan Liu, Zi-Yu Zeng et al. · Cancer Letters · 0 citations

#protein folding Oct 2026

Establishment and characterization of LNCaP-TR-BoM, a bone metastasis-derived prostate cancer cell line with an intermediate AR-attenuated phenotype

Background. Progression of prostate cancer under androgen receptor (AR) pathway-targeted therapy spans a phenotypic spectrum, from tumors that sustain AR pathway output to tumors that become independent of AR signaling. Experimental models that occupy the intermediate portion of this spectrum, in which AR is still expr...

Adrian Chao, Xin Lu · bioRxiv · 0 citations

#small language model Open access Sep 2026

Cell-type separability predicts annotation accuracy and outweighs algorithm choice: a factorial benchmark across seven scRNA paradigms

Using standardized oracle inputs and Cohen’s κ, it is found that, within the ranges tested, the major paradigms achieved comparable accuracy, and the field’s near-term gains lie in strengthening infrastructure—prioritizing tool accessibility, standardized evaluation, and robustness to pipeline variation.

Oliver Wardhana, Zi-Yu Zeng, Xin Lu · bioRxiv · 0 citations