Strategies for High-Titer and High-Quality Monoclonal Antibody Production: Cell Line Construction, Culture Medium Development, and Process Regulation in Bioreactors
This review systematically summarizes the full technological chain for efficient and high-quality mAb production, focusing on three levels: cell line construction, culture medium development, and process regulation in bioreactors, and highlights their key strategies, mechanisms, and synergistic relationships.
Xin-Wei Su, Jianquan Luo, Rong Fan et al.
· Chem & Bio Engineering · 0 citations