Author

Xue-Kun Xing

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Review Open access Oct 2026

GPR183-mediated immune cell positioning and function: an integrative perspective across ligand gradients, tissue environments, and disease stages

G protein-coupled receptor 183 (GPR183), also known as EBI2, is a chemoattractant receptor whose principal endogenous ligand is 7α,25-dihydroxycholesterol (7α,25-OHC). Its expression varies dynamically across immune-cell subsets and activation states. By sensing local 7α,25-OHC gradients, GPR183 converts tissue metabol...

Xin-Rui Lin, Xin-Yu Dong, Zhe Jiang et al. · Frontiers in Immunology · 0 citations

Review Open access Sep 2026

Regulatory Mechanisms Within Multicellular Signaling Networks in Liver Ischemia–Reperfusion Injury: A Systematic Review Focusing on Cell‐Type‐Specific Interactions

This article systematically reviews the mutual regulatory mechanisms of various liver cells during hepatic ischemia–reperfusion, focusing on intercellular signal communication and pathophysiological changes, and integrates recent advancements to evaluate their potential applications in disease prevention and treatment.

Lei Sun, Die Hu, Xue-Kun Xing · The FASEB Journal · 0 citations

Jul 2026

Bibliometric Analysis and Trends of Organoid Technology in Tissue Engineering and Disease Modeling.

The study indicates that organoid technology demonstrates substantial utility in simulating human tissue microenvironments, advancing precision medicine, and drug screening, and the development of high-throughput screening platforms and the enhancement of international collaboration systems will promote its clinical tr...

Die Hu, Lei Sun, Xue-Kun Xing · Tissue engineering. Part B,... · 0 citations