Bibliometric Analysis and Trends of Organoid Technology in Tissue Engineering and Disease Modeling.

Abstract

Organoid technology, as an innovative three-dimensional (3D) cell culture method, has undergone rapid advancement in the fields of tissue engineering and disease model construction in recent years. Using data retrieved from the PubMed database, this study employed bibliometric methods to systematically analyze 774 relevant publications from 2006 to 2026, focusing on research output, national and institutional distribution, collaboration networks, journal and author influence, and keyword evolution. The results show a significant increase in organoid research output, with China and the United States being the main contributing countries, and active international collaboration. Leading institutions, such as Harvard Medical School, occupy prominent positions in this field, with research covering multidisciplinary directions including cell culture, tissue scaffolds, microfluidic chips, and 3D bioprinting. Keyword analysis revealed core hotspots such as cell differentiation, tissue engineering methods, and multipotent stem cells, with 3D printing and induced pluripotent stem cells emerging as new research frontiers. The study indicates that organoid technology demonstrates substantial utility in simulating human tissue microenvironments, advancing precision medicine, and drug screening. Despite challenges related to vascularization, production standardization, and cost constraints, the development of high-throughput screening platforms and the enhancement of international collaboration systems will promote its clinical translation and sustainable development.