Hybridization-Mediated Reversible sgRNA Caging Enables Tumor-Selective Gene Editing for Potentiating Antitumor Immunity via cGAS Demethylation.
This study provides a versatile paradigm for conditionally controlled gene editing and highlights the therapeutic potential of cGAS demethylation in reactivating cGAS-STING pathway for antitumor immunotherapy.
Hao-Yu Zhang, Ya-Jie Li, Ye-Han Wang et al.
· Angewandte Chemie · 0 citations