Author

Xun Song

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#federated learning Open access Sep 2026

FedEdgeR: federated and privacy-preserving edgeR for differential gene expression analysis

FedEdgeR is presented, a federated edgeR implementation protected by secure multi-party computation (SMPC), covering IRLS GLM fitting, three-level dispersion estimation, and the likelihood-ratio test, which consistently outperforms Fisher, Stouffer, random-effects, and RankProd meta-analysis on every tested dataset.

Xun Song, Zhi Wei · bioRxiv · 0 citations

Open access Jul 2026

CellPilot: an agentic framework that pilots small language models through autonomous single-cell annotation

CellPilot, an agentic framework that guides a locally deployable small language model through the full single-cell analysis workflow, from raw count matrices to cluster-level annotation, suggests that structured workflow orchestration can be a critical determinant of performance in multi-step single-cell analysis.

Siqi Jiang, Cong Qi, Ye-Qing Chen et al. · bioRxiv · 0 citations