A-to-I mRNA editing is a widespread RNA modification that introduces A-to-G variations at mRNA level, enhancing transcriptomic and proteomic diversity without altering the genome. Recently, the term adaptation has gained significant attention but lacks a mechanistic classification. This article aims to discuss conceptu...
Y. Duan, Wan-Zhi Cai, Hu Li· The Innovation Insights· 0 citations
The therapeutic efficacy of protein biologics is often hampered by their rapid in vivo degradation and off-target effects. Interleukin-2 (IL-2), a cytokine promising for treating autoimmune diseases via regulatory T cell (Treg) expansion, exemplifies this challenge due to its short half-life and pleiotropic activity. H...
Jing Fang, Rui-Ling Feng, Xi-Bao Tian et al.· The Innovation Life· 0 citations
Results indicate a possible link between transcriptional remodeling, RNA editing, and functional polarization of HCC-induced neutrophils, and provide an exploratory framework for investigating ADAR-regulated RNA editing in tumor-immune communication.
Qian Cao, Y. Duan· Journal of Biological Chemis...· 0 citations
The results show that CDSs are rarely predefined in the genome, and the differential roles of predefined versus variable CDS architectures may reflect how natural selection balances molecular stability and functional innovation.
Qian Cao, Ziyi Wang, Y. Duan· BMC Genomics· 0 citations
The findings conservatively indicate that Smart-Seq may not be good at analyzing molecular diversity and that the results need to be interpreted with caution.
Y. Duan, Ji-Yao Liu, Shiwen Xu et al.· Nucleic Acids Research· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
