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Author

Ya-Ping Xue

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Oct 2026

SeqSol-FECS: An Integrated Deep Learning and Structural Modeling Framework for Protein Solubility Engineering

Escherichia coli is widely used as a workhorse for heterologous protein expression. However, insoluble protein expression is frequently encountered. The mechanisms underlying protein solubility remain incompletely understood, limiting the effectiveness of current protein solubility engineering strategies. Here, SeqSo...

Qian Guo, Xiao-Ting Zhou, Ren Zhou et al. · 0 citations
#protein folding Oct 2026

Designing a DeepPCD Strategy for Efficient Engineering Nitrilases toward Industrial Bioconversion

The integration of artificial intelligence with protein engineering has created unprecedented opportunities for enzyme discovery and the enhancement of overall catalytic performance. In this study, a novel nitrilase, BhNIT, was identified from Bradyrhizobiumhuanghuaihaiense through a computationally assisted screenin...

Xiao-Ting Zhou, Qian Guo, Yao-Fang Ding et al. · 0 citations

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