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Author

Yan-Ling Sun

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#gene editing Open access Aug 2026

Constructing an Adenine Base Editor in Escherichia coli for Fine-Tuning the 1,4-Butanediamine Biosynthetic Pathway

The engineered strain achieved a marked increase in 1,4-butanediamine production, demonstrating that promoter editing via ABE can effectively regulate metabolic flux and enhance the production of the target product, as well as serving as a valuable reference for the biosynthesis of other high-value-added chemicals.

Yan-Ling Sun, Dicheva Ma, Ke Zhao et al. · 0 citations
Open access Jul 2026

Enhancement and balance of 1,4-butanediamine biosynthesis in Escherichia coli based on modular metabolic engineering

1,4-Butanediamine is an important raw material for the synthesis of engineering plastics such as Polyamide 46 with excellent performance, which is widely used in automotive, electronics and machinery manufacturing industries. In this study, Escherichia coli BL21(DE3) was used as the starting strain to systematically mo...

Xiangxiang Sun, Zongda Li, Yan-Ling Sun et al. · 0 citations

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