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Yeji Lee

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#gene editing Open access Aug 2026

Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.

A programmable gene replacement tool, named prime assembly (PA), which adapts prime editors to produce one or two pairs of 3'-flaps on both the genome and donor DNA, allowing megabase-scale genomic excision and/or kilobase-scale donor insertion at the gene of interest.

Hojun Jung, Bada Jeong, Yong-Woo Kim et al. · 0 citations
Open access Jul 2026

Engineered ADARs enable precision A-to-G base editing of DNA.

A single-nucleotide resolution ABE created by fusing a nickase Cas9, nCas9-H840A, with the deaminase domain of ADAR, which acts on DNA:RNA hybrids, instead of TadA, which acts on single-stranded DNA in conventional ABEs.

Hyeon Woo Im, Bada Jeong, Yeji Lee et al. · 1 citation