Roles of endogenous retrovirus- and other LTR retrotransposon-derived proteins and peptides in neurological disorders, oncogenesis, and host defense.
LTR retrotransposons, including endogenous retroviruses (ERVs), constitute approximately 9% of the human genome and represent remnants of ancient mobile genetic elements. Although most of these sequences have accumulated truncations and mutations and have long been regarded as genomic relics, accumulating evidence indi...