pgRNA-m6A levels associate with HBV replication and liver function
Site-specific m6A demethylation of pgRNA1907-m6A significantly reduced HBV DNA, hepatitis B e antigen (HBeAg) and HBV pgRNA, while induced levels of interferon alfa 2 (IFN-α2) and apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) were reduced.
Chao-Qi Yang, Shan-Shan Qin, Rui-Huan Gao et al.
· Epigenetics · 0 citations