RNF5 Regulates HERP1 and OS9 Stability and Modulates Processing of an ERAD Substrate
Endoplasmic reticulum-associated degradation (ERAD) must dynamically adapt to cellular protein-folding demands, yet mechanisms regulating ERAD-associated adaptors remain incompletely defined. Here, we identify the E3 ubiquitin ligase RNF5 as a regulator of the ERAD adaptors HERPUD1 (HERP1) and OS9. RNF5 depletion incre...
Wen-Jing Yan, Yan-Yan Qu, Yong-Wang Zhong et al.
· Life · 0 citations