Programmable Enhancement of IRES-Mediated Translation via RNA-Guided eIF4G Recruitment
Internal ribosome entry sites (IRESs) enable cap-independent translation but often exhibit low and variable efficiency, limiting their use in synthetic gene circuits. Here, we present a programmable strategy to enhance IRES-dependent translation by recruiting a truncated eIF4G scaffold via engineered RNA-binding prot...
Bin-Bin Ying, Fei-Yang Zheng, Yoshinori Kawabe et al.
· Biochemistry · 0 citations