Author

Yu-Fei Cao

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Oct 2026

Metabolic Engineering of Saccharomyces cerevisiae for Flavonoid Synthesis from Acetate

Acetate is a sustainable C2 feedstock derived from CO2 electroreduction, but its conversion to complex natural products is constrained by impaired cell growth and poor metabolic compatibility. Adaptive laboratory evolution generated an evolved Saccharomyces cerevisiae strain capable of producing 536.32 mg/L of p-coum...

Mei Li, Guang-Jian Li, Yu-Tao Wang et al. · Journal of Agricultural and... · 0 citations

#protein folding Sep 2026

Ultrasound-Synchronized In Situ Crystallization Locks Transient High-Activity Enzyme Conformations within Covalent Organic Frameworks

Enzymes transiently access high-activity conformations with exposed cryptic sites and heightened substrate affinity, yet these states dissipate upon relaxation to the thermodynamic ground state once the activating perturbation is removed, leaving this catalytic potential largely inaccessible. Here we show that such f...

Hong-Li Zhou, Shuang Chen, Hai-Yue Zhou et al. · Journal of the American Chem... · 0 citations